Evidence map›Paper›PMID 41698958›Full record

ArticleNature communications2026

Structural and functional mechanisms underlying activation gate dynamics and IFM motif accessibility in human Na

Rupam Biswas, Ana Laura López-Serrano, Apoorva Purohit, Angelina Ramirez-Navarro, Hsiang-Ling Huang, Xiaolin Cheng, Sarah M Heissler, Isabelle Deschênes, Krishna Chinthalapudi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rupam BiswasDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.
Ana Laura López-SerranoDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.
Apoorva PurohitDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Angelina Ramirez-NavarroDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.
Hsiang-Ling HuangDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-5944-1252
Xiaolin ChengDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-7396-3225
Sarah M HeisslerDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-6972-7940
Isabelle DeschênesDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA. isabelle.deschenes@osumc.edu.ORCID http://orcid.org/0000-0002-1812-7267
Krishna ChinthalapudiDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA. krishna.chinthalapudi@osumc.edu.ORCID http://orcid.org/0000-0003-3669-561X

Funding

Sodium Channels and Cardiac ArrhythmiasR01HL094450 · NHLBI · OHIO STATE UNIVERSITY · PI DESCHENES, ISABELLE · 2010 to 2022
$4.0M
NHLBI NIH HHS R01 HL094450U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL094450
6 · The paper itself

Abstract

Voltage-gated sodium channels are vital for regulating excitability in muscle and nerve cells, and their dysregulation is linked to a range of diseases. However, therapeutic targeting of Na

Indexed as

Ion Channel GatingNAV1.5 Voltage-Gated Sodium ChannelAmino Acid MotifsBinding SitesCryoelectron MicroscopyHumansMolecular Dynamics SimulationSodiumNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humanSodium

Identifiers

PMID41698958
PMCPMC13022357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.