Evidence map›Paper›PMID 41698948›Full record

ArticleNature communications2026

H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants.

Jiabing Wu, Jiachen Wang, Kangxi Du, Yingping Li, Wenhao Xie, Chenxi He, Qidan Xing, Xiang Li, Xiaoyu Zhu, Zhen Wu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiabing Wu *State Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.ORCID http://orcid.org/0000-0002-6579-2681
Jiachen Wang *State Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.ORCID http://orcid.org/0000-0003-4841-5785
Kangxi Du *State Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.ORCID http://orcid.org/0000-0002-7985-7861
Yingping Li *State Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.
Wenhao XieState Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.
Chenxi HeLiver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Key Laboratory of Epigenetics and Metabolism, Ministry of Science and Technology, and Institutes of Biomedical Sciences, Fudan University, Shanghai, PR China.
Qidan XingState Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.
Xiang LiState Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.
Xiaoyu ZhuState Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.
Zhen WuState Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.
Xiaolong WuState Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.ORCID http://orcid.org/0009-0004-0368-4732
Linghao ZhangState Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.
Wen-Hui ShenInstitut de Biologie Moléculaire des Plantes, CNRS, Université de Strasbourg, Strasbourg Cédex, France.ORCID http://orcid.org/0000-0001-7988-6382
Fei LanLiver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Key Laboratory of Epigenetics and Metabolism, Ministry of Science and Technology, and Institutes of Biomedical Sciences, Fudan University, Shanghai, PR China.ORCID http://orcid.org/0000-0002-8559-7146
Jianhua GanShanghai Sci-Tech Inno Center for Infection & Immunity, State Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry and Biophysics, Fudan University, Shanghai, PR China. ganjhh@fudan.edu.cn.ORCID http://orcid.org/0000-0002-8438-8852
Bing LiuState Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China. bingliu@fudan.edu.cn.ORCID http://orcid.org/0000-0003-0222-2531
Aiwu DongState Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China. aiwudong@fudan.edu.cn.ORCID http://orcid.org/0000-0002-2075-4235

Funding

National Natural Science Foundation of China (National Science Foundation of China) NSFC31930017
6 · The paper itself

Abstract

Monomethylation of histone 3 lysine 4 (H3K4me1) marks enhancers in mammals. However, the function of H3K4me1 in plants remains largely unclear. Here, we present the genome-wide distribution of H3K4me1 in diverse species across evolution, revealing a distinctive H3K4me1 distribution pattern in land plants. To explore the function of H3K4me1 in plants, we identified an H3K4me1-specific reader protein, Early heading date 3 (Ehd3), and solved the structure of Ehd3 in complex with the H3K4me1 peptide, revealing a unique binding module differing from the previously reported PHD finger proteins. We further identified an Ehd3-binding protein, SET domain group 724 (SDG724), and the deletion of either Ehd3 or SDG724 caused similar defects in plant phenotype and changes in transcriptome and epigenome profiles. Both Ehd3 and SDG724 are enriched at chromatin regions marked by H3K4me1 but not H3K4me2 or H3K4me3. Ehd3 activates the H3K36 methyltransferase SDG724, and H3K36me2/me3 are colocalized with H3K4me1 in the genomes of the examined land plants. Collectively, our results reveal that H3K4me1 directs the establishment of H3K36me2 and H3K36me3 in land plants.

Indexed as

EmbryophytaHistonesArabidopsisChromatinGene Expression Regulation, PlantMethylationPlant ProteinsChromatinH3K4me1HistonesPlant Proteins

Identifiers

PMID41698948
PMCPMC13022364

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.