ArticleNPJ Parkinson's disease2026
SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids.
Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Intranasal drug delivery to the brain for neurodegenerative diseases: Current efforts and challenges in delivery platforms and modeling.Advanced drug delivery reviews · 2026Review
- Article
- Extracellular matrix remodelling in neurological diseases.Nature reviews. Neurology · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
Synucleinopathies, including Parkinson's disease, involve α-synuclein (SNCA) accumulation and neurodegeneration, but early molecular effects of increased SNCA dosage remain incompletely defined. We examined human midbrain organoids derived from induced pluripotent stem cells carrying SNCA triplication and an isogenic control to assess early alterations in a 3D human model. We detected early changes in signalling linked to protein synthesis and stress responses prior to pronounced neurodegeneration. Proteomic and transcriptomic analyses indicated coordinated modulation of neuronal pathways and extracellular matrix components, including enrichment of perineuronal net-associated proteins alongside reduced expression of other matrix constituents. Ribosome profiling showed selective translational buffering for subsets of neuronal and matrix-related transcripts. Imaging revealed increased pericellular and interstitial matrix structures around neurons, emerging earlier in TH
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