ArticleNature communications2026
Drug-caged drugs enable photocatalytic dual decaging of nitric oxide and anesthetics for antibacterial analgesia.
Jiqian Zhang, Guihai Gan, Chenchen Cao, Shaoqiu Zheng, Peng Wang, Xuesheng Liu, Jinming Hu
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Jiqian Zhang *Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesia and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, China.ORCID http://orcid.org/0000-0001-6360-1557 Guihai Gan *Hefei National Research Center for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui Province, China.
Chenchen CaoDepartment of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesia and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, China.
Shaoqiu ZhengHefei National Research Center for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui Province, China.
Peng WangDepartment of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesia and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, China.
Xuesheng LiuDepartment of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesia and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, China. liuxuesheng@ahmu.edu.cn.
Jinming HuHefei National Research Center for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui Province, China. jmhu@ustc.edu.cn.ORCID http://orcid.org/0000-0002-6969-1343 Funding
National Natural Science Foundation of China (National Science Foundation of China) 52425306 and 52273155National Natural Science Foundation of China (National Science Foundation of China) 82271217
6 · The paper itselfAbstract
Bacterial infections often result in significant pain, negatively impacting patient outcomes and quality of life. Conventional therapies primarily focus on pathogen eradication but frequently overlook the associated pain, thereby limiting their overall clinical effectiveness. Herein, we propose a 'drug-caged drug' strategy in which the secondary amine group of the local anesthetic tetracaine (TTC) is selectively caged by nitric oxide (NO), forming the TTC-NO prodrug. The TTC-NO prodrug is co-loaded with the photocatalyst fac-Ir(ppy)
Indexed as
Anesthetics, LocalAnti-Bacterial AgentsNitric OxideTetracaineAnalgesiaAnalgesicsAnimalsCatalysisHumansLightMethicillin-Resistant Staphylococcus aureusMiceMicellesNanoparticlesPolyestersPolyethylene GlycolsAnalgesicsAnesthetics, LocalAnti-Bacterial AgentsMicellesNitric OxidePolyestersPolyethylene GlycolsProdrugsTetracaine
Identifiers
PMID41698916
PMCPMC13022230
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390