Evidence map›Paper›PMID 41698824›Full record

ArticleGenes to cells : devoted to molecular & cellular mechanisms2026

A Temperature Increase Induces Atf1/Pcr1-Dependent Rapid Depletion of Histones in Transcriptionally Activated Gene Bodies in Fission Yeast.

Arata Hoshino, Takuya Kajitani, Masaya Oki, Tetsuji Kakutani, Soichi Inagaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes to cells : devoted to molecular & cellular mechanisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Arata HoshinoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Takuya KajitaniDepartment of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, Fukui, Japan.
Masaya OkiDepartment of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, Fukui, Japan.
Tetsuji KakutaniDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Soichi InagakiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4090-826X

Funding

Japan Society for the Promotion of Science JP20H05913Japan Society for the Promotion of Science JP21H04977Japan Society for the Promotion of Science JP22H02299Japan Society for the Promotion of Science JP23H00365Japan Society for the Promotion of Science JP24K21926Japan Society for the Promotion of Science JP25K02252Mitsubishi Foundation 202110005Precursory Research for Embryonic Science and Technology JPMJPR17Q1
6 · The paper itself

Abstract

Transcriptional regulation is central to organisms' response and adaptation to environmental changes. However, the coordination of transcriptional machinery with chromatin when rapid transcriptional changes are needed is largely unknown. Here, we studied the rapid response of histone modifications upon heat treatment of fission yeast Schizosaccharomyces pombe. We observed a significant eviction of H3 in the transcribed regions of upregulated genes, named Hasty Overheat-Triggered Differentially Occupied Genes (HOT-DOGs), including Heat Shock Protein-encoding genes. The loss of H3 in a third of the HOT-DOGs was dependent on the Atf1-Pcr1 transcription factor complex. Furthermore, the H3K9 methyltransferase Clr4 likely modulates the rate of transcription elongation and helps prevent transcriptional read-through beyond polyadenylation sites in these genes. Our results unveiled a novel function of Clr4 in regulating the dynamics of transcription within gene bodies and provided insights into how cells cope with rapid environmental changes while preserving chromatin integrity.

Indexed as

Activating Transcription Factor 1HistonesmRNA Cleavage and Polyadenylation FactorsSchizosaccharomycesSchizosaccharomyces pombe ProteinsActivating Transcription FactorsCell Cycle ProteinsGene Expression Regulation, FungalHistone-Lysine N-MethyltransferaseHot TemperatureMethyltransferasesPhosphoproteinsTranscriptional ActivationTranscription, GeneticActivating Transcription Factor 1Activating Transcription Factorsatf1 protein, S pombeCell Cycle Proteinsclr4 protein, S pombeHistone-Lysine N-MethyltransferaseHistonesMethyltransferasesmRNA Cleavage and Polyadenylation FactorsPcr1 protein, S pombePhosphoproteinsSchizosaccharomyces pombe Proteins

Identifiers

PMID41698824
PMCPMC12909096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.