ArticleBMJ open2026
Gut microbiome profile among children and adolescents living with sickle cell disease: a protocol for systematic review and meta-analysis.
Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis systematic review aims to synthesise current evidence on gut microbiome profiles among children with sickle cell disease (SCD), assess the influence of analgesic and antibiotic use, and explore the contributions of environmental factors on their gut microbiota diversity. Through identification of consistent microbial patterns and gaps in the existing literature, this review will provide vital insight into potential microbiome-targeted strategies for improving health outcomes in paediatric SCD care. METHODS AND ANALYSIS: Studies describing the gut microbiota among paediatric SCD human subjects (<18 years) will be identified by searching PubMed, Cochrane Library, Web of Science, Google Scholar and Scopus from inception to November 2025. Two independent reviewers will complete title and abstract screening, full-text review and data extraction. The grading of recommendations assessment, development and evaluation tool will be employed to assess the strength of evidence for each outcome. Extracted data will be presented in tables, and a meta-analysis will be conducted if appropriate. ETHICS AND DISSEMINATION: Ethical approval will not be required as this is a systematic review of published data. The findings will be disseminated through publications in peer-reviewed journals and presentations at relevant scientific conferences. PROSPERO REGISTRATION NUMBER: CRD420251102736.
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Registered trials
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