Evidence map›Paper›PMID 41698688›Full record

ArticleContact dermatitis2026

Formaldehyde Emissions From 2-Octyl Cyanoacrylate: Quantified Risk for Allergic Contact Dermatitis.

Daniel S Rouhani, Paul M Villalobos, Steven Zeng, Reza Ghodsi, Kavana M Sanjay, Simrin A Singh, M Mark Mofid

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contact dermatitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel S RouhaniDepartment of Surgery, Division of Plastic and Reconstructive Surgery, University of California San Francisco, San Francisco, California, USA.
Paul M VillalobosDepartment of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
Steven ZengDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Reza GhodsiZilkha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Kavana M SanjaySan Diego Skin, Inc., La Jolla, California, USA.
Simrin A SinghSan Diego Skin, Inc., La Jolla, California, USA.
M Mark MofidDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-2214-1870

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background2-octyl-cyanoacrylate-mesh-systems are used as topical wound closure devices in surgery and are increasingly associated with allergic and irritant contact dermatitis. Formaldehyde, a degradation byproduct of cyanoacrylates and a potent sensitiser, is believed to be associated with this reaction, but emission levels have not been quantified.

methodsA bench microchamber study was performed using standardised 4 × 4 cm polyester mesh with applied 2-octyl cyanoacrylate adhesive in a 30 L chamber (25°C, 1 atm, 1 h

resultsDermal loads at 14 days reached 8.4 μg/cm

conclusion2-octyl-cyanoacrylate-mesh-systems emit formaldehyde at levels exceeding sensitization and inhalation thresholds, raising concern for dermal and respiratory exposure, particularly in sensitised individuals. Prior sensitisation from adhesives such as nail, eyelash or super glues may heighten risk.

Indexed as

CyanoacrylatesDermatitis, Allergic ContactFormaldehydeWound Closure TechniquesHumansCyanoacrylatesFormaldehydeoctyl 2-cyanoacrylateallergic contact dermatitiscyanoacrylateDermabond Prineoformaldehydeskin adhesives

Identifiers

PMID41698688
PMCPMC13139693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.