Evidence map›Paper›PMID 41698685›Full record

SynthesisJournal of applied toxicology : JAT2026

The Impact of Genotoxicity in Coke Oven Workers: Systematic Review With Meta-Analysis.

Thiago Guedes Pinto, Vinícius Fialho do Nascimento, Giovanna Abreu Holanda Guerra, Wilton Mitsunari Takeshita, Raquel Alves Sales, Andrea Cristina de Moraes Malinverni, Luciana Lopes Guimaraes, Daniel Araki Ribeiro

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thiago Guedes PintoDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, São Paulo, Brazil.
Vinícius Fialho do NascimentoDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, São Paulo, Brazil.
Giovanna Abreu Holanda GuerraDepartment of Pathology, Laboratory of Molecular and Experimental Pathology, Federal University of São Paulo, UNIFESP, São Paulo, São Paulo, Brazil.
Wilton Mitsunari TakeshitaDepartment of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.ORCID 0000-0001-5682-1498
Raquel Alves SalesDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, São Paulo, Brazil.
Andrea Cristina de Moraes MalinverniDepartment of Pathology, Laboratory of Molecular and Experimental Pathology, Federal University of São Paulo, UNIFESP, São Paulo, São Paulo, Brazil.
Luciana Lopes GuimaraesSanta Cecilia University, Santos, São Paulo, Brazil.
Daniel Araki RibeiroDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, São Paulo, Brazil.ORCID 0000-0001-5057-4983

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 001
6 · The paper itself

Abstract

This systematic review (SR) with meta-analysis investigates the genotoxicity potential of coke oven workers (COWs) exposed to polycyclic aromatic hydrocarbons (PAHs) through a comprehensive analysis of studies retrieved from PubMed, SCOPUS, and Web of Science. The comparisons were defined as standardized mean difference (SMD), and 95% confidence intervals (CIs) were established. A systematic search conducted in May 2025 identified 21 relevant studies, which employed different assays, such as the micronucleus assay (MA) and the comet assay (CA) in order to assess DNA damage. The outcomes suggested that 21 of the reviewed studies observed genotoxic effects related to this exposure, with 20 inducing micronucleus formation and chromosomal abnormalities. As for the quality assessment, a total of 18 studies were classified as Strong, and three (out of 21) were deemed as Moderate. No study was categorized as Weak, which proves our findings can be considered trustworthy. The meta-analysis (six studies) revealed a statistically significant difference between COWs and the control group, for both the MN (SMD = 0.70, 95% CI, 0.26-1.15, p = 0.002) and CA (SMD = 0.86, 95% CI, 0.34-1.38, p = 0.001) with high heterogeneity. We concluded that there is a potential for genotoxicity in COWs. This certainly shows the importance of further investigation and regulatory oversight to ensure coke oven professionals' safety. Also, we understand such findings are vital for clarifying the role of biomarkers related to genotoxicity due to this occupational exposure.

Indexed as

Air Pollutants, OccupationalCokeDNA DamageMutagensOccupational ExposurePolycyclic Aromatic HydrocarbonsChromosome AberrationsComet AssayHumansMicronucleus TestsAir Pollutants, OccupationalCokeMutagensPolycyclic Aromatic Hydrocarbonscoke oven workersgenotoxicitypolycyclic aromatic hydrocarbons

Identifiers

PMID41698685
PMCPMC13040412

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.