Evidence map›Paper›PMID 41698407›Full record

ArticleAmerican journal of clinical pathology2026

Optic nerve sheath meningiomas harbor distinct genetic variants.

Samuel W Hulbert, Gianluca Lopez, Liam Chen, Suping Chen, Aparna Pallavajjala, Lisa Haley, Aaron J Z Nelson, Arpita Maniar, Michael Kazim, Timothy Sullivan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of clinical pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Samuel W HulbertUniversity of California, Los Angeles, CA, United States.ORCID 0000-0003-0369-0150
Gianluca LopezUniversity of California, Los Angeles, CA, United States.ORCID 0000-0002-9262-1212
Liam ChenUniversity of Minnesota, Minneapolis, MN, United States.ORCID 0000-0001-5553-5473
Suping ChenSchool of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Aparna PallavajjalaSchool of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Lisa HaleySchool of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Aaron J Z NelsonDuke Health, Durham, NC, United States.
Arpita ManiarDuke Eye Center, Durham, NC, United States.
Michael KazimDepartment of Ophthalmology and Surgery, Columbia University Irving Medical Center, New York, NY, United States.
Timothy SullivanThe University of Queensland, Pathology Queensland, Brisbane, Australia.
Charles G EberhartSchool of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Fausto J RodriguezUniversity of California, Los Angeles, CA, United States.ORCID 0000-0001-8662-1219
Neil R MillerSchool of Medicine, Johns Hopkins University, Baltimore, MD, United States.

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
NCI NIH HHS P30 CA006973NCI NIH HHS P50 CA211015NIH HHS P30 CA006973
6 · The paper itself

Abstract

objectiveBoth primary optic nerve sheath meningiomas (pONSMs) and secondary optic nerve sheath meningiomas (sONSMs) pose clinical challenges because standard treatments such as surgical debulking and radiation therapy can further damage the optic nerve, producing permanent visual loss. The molecular pathology of primary skull base meningiomas is becoming clearer. However, by comparison, pONSMs and sONSMs have not been studied adequately with contemporary high-throughput molecular genetic techniques, which is the primary aim of this study. This is a crucial issue because these tumors may harbor distinct genetic alterations that render them susceptible to targeted therapy, allowing for vision preservation or even visual improvement.

methodsA total of 18 optic nerve sheath meningiomas, of which 11 were pONSMs and 7 were sONSMs, were obtained from 3 different institutions and underwent next-generation sequencing.

resultsWe found that pONSMs and sONSMs harbor gene variants previously identified in other meningiomas but also distinct alterations in genes implicated in cell signaling, transcriptional regulation, and DNA damage repair.

conclusionsThese findings expand our understanding of a relatively understudied specific meningioma with unique therapeutic challenges.

Indexed as

Meningeal NeoplasmsMeningiomaOptic Nerve NeoplasmsAdultAgedFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedMutationmeningiomamutationsnext-generation sequencingNGSoptic nerveoptic nerve sheath

Identifiers

PMID41698407
PMCPMC13368607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.