Evidence map›Paper›PMID 41698386›Full record

ArticleRedox report : communications in free radical research2026

XFM and HERFD-XAS studies of selenium in tissues and whole blood from mice supplemented with potentially therapeutic selenocompounds.

Ani T Baker, Tamara Ortiz-Cerda, Kangzhe Xie, Jordan Hunter, Iliya Dragutinovic, Jonathan C Morris, Linda I Vogt, Graham N George, Dimosthenis Sokaras, Daryl L Howard and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox report : communications in free radical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ani T BakerDiscipline of Chemistry, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-1008-6384
Tamara Ortiz-CerdaDepartamento de Citología e Histología Normal y Patológica, Facultad de medicina, Universidad de Sevilla, Seville, Spain.ORCID 0000-0002-4681-9383
Kangzhe XieRedox Biology Group, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.ORCID 0009-0009-2552-6950
Jordan HunterRedox Biology Group, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Iliya DragutinovicSchool of Chemistry, Faculty of Science, Kensington, UNSW Sydney, NSW, Sydney, Australia.ORCID 0009-0001-4689-5976
Jonathan C MorrisSchool of Chemistry, Faculty of Science, Kensington, UNSW Sydney, NSW, Sydney, Australia.ORCID 0000-0002-5109-9069
Linda I VogtDepartment of Geological Sciences, University of Saskatchewan, Saskatoon, Canada.ORCID 0000-0002-0835-0457
Graham N GeorgeDepartment of Geological Sciences, University of Saskatchewan, Saskatoon, Canada.ORCID 0000-0002-0420-7493
Dimosthenis SokarasStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID 0000-0001-8117-1933
Daryl L HowardAustralian Synchrotron, ANSTO, Clayton, Australia.ORCID 0000-0001-6071-2382
Paul K WittingRedox Biology Group, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.ORCID 0000-0003-2237-7004
Hugh H HarrisDiscipline of Chemistry, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-3472-8628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSelenium nanoparticles (SeNPs) and selenoneine (SeN) are prospective nutritional supplements and therapeutic agents postulated to counteract Se deficiency and alleviate oxidative stress induced by various pathological conditions.

methodsX-ray fluorescence microscopy (XFM) and high energy resolution fluorescence detected X-ray absorption spectroscopy (HERFD-XAS) investigated Se distribution and speciation in mice fed supranutritional doses of SeNPs (10 mg Se/kg in feed) and SeN (5 mg Se/kg in feed).

resultsMice fed control and SeNP diets showed equivalent Se distributions in the liver and testes, however, Se concentrations were elevated in the renal tubules of mice supplemented with SeNPs. Negligible differences in the composition of selenospecies were detected in tissues from mice fed SeNPs and control diets. Mice supplemented with SeN exhibited significant elevations in Se across all analysed tissues. Se Kα

conclusionThese results support the hypothesised

Indexed as

Organoselenium CompoundsSeleniumAnimalsDietary SupplementsHistidineLiverMaleMiceMicroscopy, FluorescenceNanoparticlesTissue DistributionX-Ray Absorption SpectroscopyHistidineOrganoselenium CompoundsSeleniumselenoneineantioxidantdietary supplementfluorescencenanoparticlesSeleniumselenoneinespectroscopytherapeutic

Identifiers

PMID41698386
PMCPMC12912245

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.