ArticleJournal of animal science2026
MiR-31 enhances porcine oocyte maturation via MAPK8/JNK-mediated cumulus expansion and cytoplasmic maturation.
Article in Journal of animal science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- MicroRNAs as Regulators of Reproductive Function: From Gametogenesis to Pregnancy.Journal of developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study elucidates the molecular mechanism by which porcine ovarian cumulus cell-derived miR-31 regulates oocyte IVM through the MAPK8/JNK signaling pathway, with particular emphasis on its biological roles in cumulus cell expansion and oocyte maturation quality. The experimental design comprised four treatment groups: miR-31 mimics group, mimics negative control (NC) group, miR-31 inhibition group, and inhibition NC group. The results showed: 1) miR-31 overexpression significantly enhanced cumulus cell expansion processes, upregulating PTGS2 (P < 0.05) and PTX3 (P < 0.01) gene expression, while concurrently increasing oocyte maturation rates (P < 0.05). 2) Oocyte quality analysis revealed that miR-31 overexpression induced: elevated mitochondrial membrane potential (P < 0.05); increased ATP production (P < 0.05); reduced lipid droplet size (P < 0.05) with concurrent quantity increased (P < 0.05); improved redox homeostasis (P < 0.05). Conversely, miR-31 inhibition demonstrated opposing effects: elevated cortical granule misdistribution rate (P < 0.05); Significant activation of MAPK8/JNK pathway activity (P < 0.01). In conclusion, this study demonstrates that miR-31 coordinates cumulus cell expansion with oocyte metabolic reprogramming by targeting MAPK8, thereby enhancing nuclear-cytoplasmic maturation synchrony.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.