ArticleCancer reports (Hoboken, N.J.)2026
Androgen Receptor Signaling Inhibitors for Metastatic Hormone Sensitive Prostate Cancer in Asians: Indirect Comparison.
Article in Cancer reports (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Androgen Receptor Signaling Inhibitors for Metastatic Hormone Sensitive Prostate Cancer in Asians: Indirect Comparison.Cancer reports (Hoboken, N.J.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundAndrogen receptor signaling inhibitors (ARSI) combined with androgen deprivation therapy (ADT) have demonstrated significant survival benefits in metastatic hormone-sensitive prostate cancer (mHSPC) in several clinical trials. However, data specifically in Asian patients remain limited, with individual subgroup analyses showing trends that did not reach statistical significance. We conducted a pooled analysis to provide additional evidence regarding the efficacy of ARSI plus ADT in Asian patients with mHSPC.
methodsWe systematically identified clinical trials reporting overall survival (OS) outcomes for ARSI-based doublet therapy in Asian patients with mHSPC. Individual patient data (IPD) were reconstructed from published Kaplan-Meier curves. Data sources included the TITAN Asian subpopulation analysis, the TITAN Japanese subpopulation, and the LATITUDE Japanese subpopulation. Reconstructed data were validated against original hazard ratios (HR) and curves. Pooled survival analyses were performed for the overall Asian cohort and separately for Japanese patients only.
resultsA total of 291 reconstructed IPDs were analyzed (146 ARSI plus ADT, 145 placebo plus ADT). In the overall Asian cohort, the 3-year OS was 85.2% with ARSI plus ADT versus 77.6% with placebo plus ADT, representing a 32% reduction in the risk of death (HR = 0.68, 95% CI 0.44-1.03, p = 0.07). In the Japanese subpopulation, 3-year OS was 77.4% versus 72.4%, with a 45% reduction in death risk (HR = 0.55, 95% CI 0.29-1.04, p = 0.07). Neither analysis reached statistical significance.
conclusionThis exploratory analysis observed a trend toward improved survival with ARSI plus ADT in Asian patients with mHSPC that did not achieve statistical significance. Prospective studies are needed to validate these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.