ArticleBriefings in bioinformatics2026
Human messenger RNA harbors widespread noncoding splice isoforms.
Article in Briefings in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Premessenger RNA transcribed from canonical protein-coding genes is frequently alternatively spliced into diverse mature mRNA isoforms, thus translating into various protein products. However, it remains unknown whether human mRNA from a protein-coding gene harbors noncoding splice isoforms in the genome. Herein, we discovered 15 836 mRNA noncoding isoforms across 7298 protein-coding genes in human. mRNA noncoding isoforms are mainly produced by alternative splicing and polyadenylation, which display tissue-specific distributions and involve in RNA processing pathways. Notably, mRNA noncoding isoforms are frequently upregulated in cancer. Differentially expressed mRNA noncoding isoforms are associated with the cancer hallmarks and can independently predict patient survival. These findings discovered human mRNA harbors widespread noncoding splice isoforms and highlight the dual characters of mRNA accommodating protein-translation isoforms and regulatory noncoding isoforms, providing a new dimension for deeper insights into the functional duality of human mRNA.
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