ArticleDevelopmental neuroscience2026
Modular Phosphoprotein Signatures Link Rac1 Inhibition to Neurite Morphogenesis in a Dose-Dependent Manner.
Article in Developmental neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionPrecise regulation of neurite initiation, elongation, and branching is critical for neuronal network formation. Rac1, a key regulator of cytoskeletal remodeling, influences neurite morphogenesis through protein phosphorylation-mediated signaling, but the global phosphorylation landscape that governs Rac1-mediated morphogenesis remains unknown.
methodTo address this knowledge gap, we performed phosphoproteomics profiling of primary rat cortical neurons treated with 3, 10, or 30 µ<sc>m</sc> of a Rac1 inhibitor for 48 h to evaluate phosphoprotein dynamics. Phosphorylation levels of 167 signaling proteins were quantified using a targeted phospho-antibody array and correlated with neuron count, neurite count and length, and branch point count.
resultsCorrelation analysis identified morphology-specific phosphoproteins, such as Tau (Thr181), GluR1 (Ser863), TrkB (Tyr515), and Merlin (Ser10), whose phosphorylation levels were significantly altered across three Rac1 inhibitor concentrations, and multiple phosphorylation sites showed dose-specific correlations with neurite morphology features.
conclusionThese results define a correlation-based framework linking phosphoprotein signaling to neurite morphology and offer novel insights into neurodevelopmental processes, neuronal disorders, and developmental neurotoxicity.
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