Evidence map›Paper›PMID 41697643›Full record

ArticlePharmacoEconomics2026

From Paper to Platform: Updating the Dutch Costing Manual and Launching a Web Application.

Leona Hakkaart-van Roijen, Stijn B Peeters, Vivian Reckers-Droog, Silvia Evers, Ben Wijnen, Leonie M Huis In 't Veld, Frederick W Thielen, Tim A Kanters

Abstract read
In one paragraph

Article in PharmacoEconomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leona Hakkaart-van RoijenErasmus School of Health Policy & Management, Erasmus University Rotterdam, Burgemeester Oudlaan 50 KAMER EB-09, 3062 PA, Rotterdam, The Netherlands. hakkaart@eshpm.eur.nl.ORCID http://orcid.org/0000-0002-3122-7713
Stijn B PeetersErasmus School of Health Policy & Management, Erasmus University Rotterdam, Burgemeester Oudlaan 50 KAMER EB-09, 3062 PA, Rotterdam, The Netherlands.ORCID http://orcid.org/0009-0004-3684-3584
Vivian Reckers-DroogErasmus School of Health Policy & Management, Erasmus University Rotterdam, Burgemeester Oudlaan 50 KAMER EB-09, 3062 PA, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-8722-3431
Silvia EversDepartment of Health Services Research, Faculty of Health Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-1026-570X
Ben WijnenTrimbos Institute, Center for Economic Evaluation and Machine Learning, Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-7993-1905
Leonie M Huis In 't VeldDepartment of Care, National Health Care Institute, Diemen, The Netherlands.
Frederick W ThielenErasmus School of Health Policy & Management, Erasmus University Rotterdam, Burgemeester Oudlaan 50 KAMER EB-09, 3062 PA, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-0312-5891
Tim A KantersErasmus School of Health Policy & Management, Erasmus University Rotterdam, Burgemeester Oudlaan 50 KAMER EB-09, 3062 PA, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0129-7961

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe Dutch costing manual, part of the national guideline for economic evaluations, provides reference prices and standardized cost calculation methods to ensure transparency and comparability. Since its last update in 2015, new evidence, updated cost data, and user needs prompted an updated version to reflect current best practices and expand scope. The aim of this article is to present the update of the costing manual and the introduction of the web application facilitating regular updates.

methodsThe update of the costing manual followed a three-step approach. First, improvement needs were identified by user surveys and experts. Secondly, methodological guidance was revised using recent literature, national data sources, and expert input. Thirdly, the reference prices were updated. In parallel, a technical web application was developed and tested to facilitate ongoing digital access and regular updates.

resultsThe updated costing manual consists of revised and updated references prices, including expanded intersectoral reference prices (e.g., education and justice). Clearer methodological guidance and improved transparency were established. Testing showed that the web-based application was intuitive to use and accurately reproduced reference prices consistent with the updated costing manual.

conclusionsThe costing manual was updated in line with the recent guidelines for economic evaluations. The manual is a comprehensive manual for use in costing studies for economic evaluations in healthcare from a societal perspective. The web-based application translated the costing manual into a practical digital tool, automating cost calculations and demonstrated usability, accuracy, and consistency with the manual.

Indexed as

Costs and Cost AnalysisEconomics, PharmaceuticalInternetManuals as TopicGuidelines as TopicHumansNetherlands

Identifiers

PMID41697643
PMCPMC13186881

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.