Observational studyEndocrine2026
Patterns and persistence of use, effectiveness, safety, clinical inertia, and adherence related to Levothyroxine treatment with real-world evidence. An observational, longitudinal and retrospective study.
Observational study in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOver- and undertreatment of chronic diseases are common. In this context, real-world data on the use of levothyroxine are limited. The aim was to determine the patterns of use, persistence, effectiveness, safety, clinical inertia, and adherence related to levothyroxine treatment in a group of patients with thyroid disease in Colombia. MATERIALS AND
methodsThis was an observational study of patients treated with levothyroxine. Clinical records were reviewed, and the minimum patient follow-up was one year. Descriptive, bivariate and multivariate analyses were performed.
resultsA total of 398 patients were identified; the median age was 53.5 years, and 71.1% were women. A total of 76.9% of the patients received levothyroxine for clinical hypothyroidism, and few adverse events occurred (4.3%). 52% of the patients were not on goal at their first thyroid-stimulating hormone (TSH) checkup. Only 36.4% had a second TSH control appointment, but among them, 65.1% did not reach their goals; moreover, 31.7% demonstrated clinical inertia. The medication possession ratio was 66.8% (≥ 80%: 31.4%), and 47.7% of the patients showed persistent use at one year. The presence of adverse events was associated with a lower probability of persistent use (OR:0.16; 95%CI:0.04–0.64).
conclusionsClinical inertia and poor disease control were common, whereas rates of adherence to and persistence with levothyroxine treatment were low. However, patients aged ≥ 40 years, those with a high educational level and chronic comorbidities, and those who habitually attended TSH control appointments were more likely to be persistent with their treatment at the one-year follow-up.
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