ArticleAnnals of surgical oncology2026
Persistent Systemic Inflammation Mediates the Impact of Postoperative Complications on Survival After Gastric Cancer Surgery.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Immune-inflammatory-fibrinogen score as a novel prognostic biomarker in patients with gastric cancer undergoing radical gastrectomy: a multicenter study.World journal of surgical oncology · 2026Trial
- Dynamic machine learning model integrating resting energy expenditure for predicting postoperative complications after gastrectomy for gastric cancer.Journal of cancer research and clinical oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundPostoperative complications (POCs) are associated with poor long-term outcomes in gastric cancer. However, the underlying biologic mechanisms remain unclear, and systemic inflammation may mediate this association.
methodsThis study retrospectively analyzed 4177 gastric cancer patients who underwent curative gastrectomy between 2013 and 2018. The neutrophil-to-lymphocyte ratio (NLR) was assessed preoperatively (pre-NLR), on postoperative day 2 (early NLR), and 3 months postoperatively (late NLR). Multivariable Cox and logistic regression models assessed the associations of NLR and POCs with survival and complication risk.
resultsFor 20.3% of the patients, POCs occurred and were associated with significantly higher NLR at all time points. In the multivariable analysis, early and late NLR independently predicted complication risk. In the Kaplan-Meier survival analysis, POCs were significantly associated with worse overall survival (OS) (hazard ratio [HR], 1.80; p < 0.001) and disease-specific survival (DSS) (HR, 1.80; p < 0.001). However, in multivariate COX regression, POCs were not independently associated with OS or DSS, whereas late NLR remained a significant predictor for both OS (HR, 1.02; p = 0.049) and DSS (HR, 1.03; p = 0.008). When stratified by POC status, high late NLR was significantly associated with worse OS (HR, 2.776; p < 0.001) and DSS (HR, 2.677; p < 0.001) in the POC group. In the no-POC group, high late NLR also was associated with worse OS (HR, 1.587; p < 0.001), but not DSS (HR, 1.274; p = 0.150).
conclusionsPersistent systemic inflammation, reflected by elevated late NLR, is a key mediator of the relationship between POCs and survival. Monitoring persistent inflammation may improve risk stratification and guide management strategies for gastric cancer patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.