Evidence map›Paper›PMID 41697463›Full record

Trial reportEndocrine2026

The association between early diagnosis of gestational diabetes and maternal-neonatal outcomes: a secondary analysis of the digest trial.

Sarah Dib, Nan Luo, Danielle L Jones, Suzanne Smith, Roy Taylor, Helen R Murphy, Laura C Kusinski, Claire L Meek

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah DibLeicester Diabetes Centre and Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester General Hospital, Gwendoline Road, Leicester, LE5 4PW, UK.
Nan LuoLeicester Diabetes Centre and Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester General Hospital, Gwendoline Road, Leicester, LE5 4PW, UK.
Danielle L JonesInstitute of Metabolic Science - Medical Research Laboratories, Cambridge Biomedical Campus, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK.
Suzanne SmithInstitute of Metabolic Science - Medical Research Laboratories, Cambridge Biomedical Campus, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK.
Roy TaylorMagnetic Resonance Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, Newcastle, NE4 5PL, UK.
Helen R MurphyUniversity of East Anglia, Bob Champion Building, Research Park, Rosalind Franklin Rd, Norwich, NR4 7UQ, UK.
Laura C Kusinski *Leicester Diabetes Centre and Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester General Hospital, Gwendoline Road, Leicester, LE5 4PW, UK.
Claire L Meek *Leicester Diabetes Centre and Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester General Hospital, Gwendoline Road, Leicester, LE5 4PW, UK. cm881@leicester.ac.uk.

Funding

Diabetes UK 17/0005712European Foundation for the Study of Diabetes - Novo Nordisk Foundation Future Leaders' Award NNF19SA058974
6 · The paper itself

Abstract

purposeTo determine whether early gestational diabetes (GDM) differs from later GDM in maternal characteristics and perinatal outcomes.

methodsThis is a secondary analysis of an energy-restricted dietary intervention in GDM (DiGest) randomized controlled trial. We compared maternal weight, glycemia, and pregnancy/neonatal outcomes between the early GDM (< 20 weeks, n = 118) and standard GDM diagnosis (21–28 weeks, n = 299) groups.

resultsEarly GDM was associated with higher antenatal (40 vs. 38 mmol/mol; p = 0.017) and postnatal HbA1c (38 vs. 36 mmol/mol; p = 0.002) and higher risk of diabetes/prediabetes postnatally (19 vs. 6%; p = 0.003). Despite higher medication requirements, perinatal outcomes did not differ. Lower gestational weight gain (2.5 vs. 5.3 kg, p = 0.003) and comparable glycemia at 36 weeks were found. Timing of diagnosis did not impact the effect of the DiGest intervention.

conclusionEarly GDM reflects more severe underlying hyperglycemia, but timely treatment and reduced gestational weight gain can offset adverse perinatal risks.

Indexed as

Diabetes, GestationalPregnancy OutcomeAdultBlood GlucoseEarly DiagnosisFemaleGestational Weight GainGlycated HemoglobinHumansInfant, NewbornPregnancyBlood GlucoseGlycated HemoglobinDietary interventionEarly gestational diabetesGestational diabetesNeonatal outcomesTiming of diagnosisWeight management

Identifiers

PMID41697463
PMCPMC12909440

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.