ArticleArchives of microbiology2026
Characterization and targeting of deleterious mutations in Carbapenemase-producing Klebsiella pneumoniae: insights from variant calling, Computer-aided drug design, and DFT analysis.
Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- In silico genomic analysis of resistome, virulome, and mobilome of β-lactamase-producing Klebsiella pneumoniae.Scientific reports · 2026Article
- WGS-based in silico analysis of clinically-associated Klebsiella pneumoniae genomes: insights into antimicrobial resistance, virulence determinants, and plasmid dynamics.Molecular genetics and genomics : MGG · 2026Article
- A comparative genomic approach to identify determinants of meropenem resistance inFrontiers in microbiology · 2026Article
- Repurposing the angiotensin II receptor blocker valsartan to inhibit penicillin-binding protein 3 and its mutants inFrontiers in bioinformatics · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The emergence of Carbapenemase-producing Klebsiella pneumoniae (CP-KP) strains is becoming a significant global concern. Rising resistance rates in these strains significantly impact available treatment options. Therefore, this present research aims to identify the existence of antibiotic-resistance genes in clinical isolates of CP-KP strains. Whole-genome sequencing data from 17 CP-KP isolates were analyzed to identify genetic variants associated with antibiotic resistance. Among the 85 variants, a deleterious mutation, E466D, was identified in DNA gyrase B (GyrB), associated with fluoroquinolone (FQ) resistance. Therefore, flavonoids were used to target mutated GyrB. Flavonoids have been extensively investigated for their antibacterial properties, as they tend to inhibit the growth of many pathogenic microorganisms, including multidrug-resistant bacteria. A total of 222 flavonoids were subjected to virtual screening against the GyrB. The docking affinity of all the ligands with GyrB was within the range of - 3.7 to - 7.9 kcal mol
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