ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Microvascular markers in systemic sclerosis: a comparative OCT-angiography and nailfold videocapillaroscopy study.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo investigate the effect of disease duration on retinal microvasculature in patients with systemic sclerosis (SSc), and to explore its correlation with nailfold videocapillaroscopy (NFC) findings and systemic organ involvement.
methodsPatients were divided into subgroups according to disease duration (≤5 years, >5 years, <10 years, ≥10 years). Retinal microvasculature was evaluated by OCT-A in the superficial (SCP) and deep (DCP) plexuses, and peripheral microcirculation was assessed by NFC. Correlations between retinal microvascular parameters, disease duration, systemic involvement, and nailfold capillary density were analyzed.
resultsThis cross-sectional study included 37 SSc patients without retinopathy and 37 healthy controls. The mean duration of disease was 10.5±7.4 (1-30, median: 10.5 years). Central foveal thickness was significantly higher in the SSc group than in controls (p < 0.001). The VD values of SSc patients in both plexuses were significantly lower compared to the healthy control group (p < 0.05, for all). In subgroup analyses, SCP VD was significantly higher in the whole, parafoveal, and perifoveal areas in the SSc-<10y group compared with the SSc-≥10y group (p=0.03, p=0.025, p=0.005). NFC data revealed that the mean capillary number was significantly higher in SSc-<10 y compared to SSc≥10 y (p=0.043). Capillary density was positively correlated with SCP VD (whole; r = 0.606, p < 0.001, parafovea; r=0.487 p=0.002, perifovea, r=0.603 p<0.001).
conclusionThe study findings indicate that SCP-VD may serve as a surrogate quantitative marker of systemic vascular involvement during the progressive course of SSc. OCT-A holds promise as a robust, non-invasive modality for disease monitoring and prognosis.
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