Evidence map›Paper›PMID 41697341›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

An uncommon culprit: PPI-induced acute tubulointerstitial nephritis in a teenager.

Rehna K Rahman, Huda Alghfeli, Mayada Raya, Sahla Kallada, Mohammad Fahim Tungekar

Abstract readCase Reports
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rehna K RahmanDepartment of Pediatrics, Burjeel Medical City, Mohamed Bin Zayed City, Abu Dhabi, UAE. drrehnashabeer@gmail.com.
Huda AlghfeliDepartment of Pediatrics, Burjeel Medical City, Mohamed Bin Zayed City, Abu Dhabi, UAE.
Mayada RayaDepartment of Pediatrics, Burjeel Medical City, Mohamed Bin Zayed City, Abu Dhabi, UAE.
Sahla KalladaDepartment of Pediatrics, Burjeel Medical City, Mohamed Bin Zayed City, Abu Dhabi, UAE.
Mohammad Fahim TungekarUranologics Ltd, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proton pump inhibitor (PPI)-induced acute tubulointerstitial nephritis (ATIN) is rarely recognized in children. A 16-year-old boy presented with a 2-month history of vomiting, abdominal pain, and weight loss and had received PPIs repeatedly. He had elevated creatinine, metabolic acidosis, sterile pyuria, glucosuria, and markedly increased urine β2-microglobulin. Ultrasound showed enlarged echogenic kidneys. Despite hydration, kidney function did not improve. Kidney biopsy revealed T lymphocyte-predominant tubulointerstitial inflammation with eosinophils, consistent with hypersensitivity-mediated ATIN due to PPI use. He recovered fully with corticosteroids and cessation of PPI use. Concurrent Helicobacter pylori gastritis was treated with a PPI-free eradication regimen. This case highlights the importance of considering PPI-associated ATIN in unexplained pediatric AKI.

Indexed as

Nephritis, InterstitialProton Pump InhibitorsAdolescentBiopsyGastritisHelicobacter InfectionsHelicobacter pyloriHumansKidneyMaleProton Pump InhibitorsAcute tubulointerstitial nephritisAdolescentDrug-induced kidney injuryProton pump inhibitors

Identifiers

PMID41697341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.