ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
An integrated in vitro and in silico approach to assess the potential inhibitory actions of auxins on human placental glutathione S-transferase P1-1.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Glutathione S-transferases (GSTs) are multifunctional enzymes involved in the metabolism of a wide variety of xenobiotics and endogenous compounds. Since some GST isozymes are overexpressed in a variety of malignancies and have been shown to play roles in the development of drug resistance, GSTs have become a promising therapeutic target. Although numerous natural and plant-derived compounds have been evaluated as GST inhibitors, the interaction between human GSTP1-1 and auxins-indole-derived plant hormones that are also detectable in human biological systems-has not been previously characterized. The present study aimed to investigate whether selected auxins can modulate the activity of human placental GSTP1-1 (hpGSTP1-1) and to elucidate the mechanistic and structural basis of any interactions. The inhibitory effects of indole-3-acetic acid (IAA), indole-3-propionic acid (IPA), and indole-3-butyric acid (IBA) on hpGSTP1-1 were evaluated using in vitro enzyme kinetic assays. IC
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