ReviewNaunyn-Schmiedeberg's archives of pharmacology2026
Current status and research trends of coptisine: a bibliometric analysis (1995 to 2025).
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Coptisine, a significant isoquinoline alkaloid, has garnered extensive attention for its pharmacological activities, such as antibacterial and anti-inflammatory effects. In recent years, driven by the growing interest in natural medicinal plants, research on coptisine has intensified. However, a systematic bibliometric analysis to map the knowledge structure of this field remains lacking. This study retrieved publications related to coptisine from the Web of Science Core Collection (WoSCC) database covering the period 1995 to 2025 and conducted a bibliometric analysis to identify research hotspots and trends. Data analysis and visualization were performed using VOSviewer, CiteSpace, and the R package "bibliometrix". A total of 626 documents were identified, with China ranking first in publication volume, followed by South Korea. The Chinese Academy of Medical Sciences, the Chinese Academy of Sciences, and Chengdu University of Traditional Chinese Medicine were the most prominent institutions. The Journal of Ethnopharmacology published the most articles, and Hailin Qin, Xuegang Li, and Xiaoli Ye were among the most productive authors. The analysis revealed that early research focused on the extraction and purification of coptisine, while the pharmacological mechanisms of coptisine in cardiovascular diseases and cancer represent the current research hotspots. This study maps the global knowledge landscape of coptisine research, highlights emerging trends, and provides a valuable reference for future investigations.
Indexed as
Identifiers
41697319What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.