Evidence map›Paper›PMID 41697275›Full record

ArticleExperimental physiology2026

α-Adrenergic blockade impairs ductus venosus shunting during an acute period of fetal hypoxaemia without further deficits to cerebral oxygen delivery.

Jack R T Darby, Stacey L Holman, Brahmdeep S Saini, Sunthara Rajan Perumal, Mike Seed, Christopher K Macgowan, Janna L Morrison

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jack R T DarbyEarly Origins of Adult Health Research Group, Robinson Research Institute, School of Pharmacy and Biomedical Sciences, College of Health, Adelaide University, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0001-7114-3920
Stacey L HolmanEarly Origins of Adult Health Research Group, Robinson Research Institute, School of Pharmacy and Biomedical Sciences, College of Health, Adelaide University, Adelaide, South Australia, Australia.
Brahmdeep S SainiUniveristy of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-3272-3812
Sunthara Rajan PerumalSouth Australian Health & Medical Research Institute, Preclinical, Imaging & Research Laboratories, Adelaide, South Australia, Australia.
Mike SeedUniveristy of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-7330-234X
Christopher K MacgowanUniveristy of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-7016-0662
Janna L MorrisonEarly Origins of Adult Health Research Group, Robinson Research Institute, School of Pharmacy and Biomedical Sciences, College of Health, Adelaide University, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0002-8602-8519

Funding

ARC Discovery Project DP190102263ARC Future Fellowship FT170100431
6 · The paper itself

Abstract

The fetal circulation has unique shunts, including the ductus venosus (DV), the tone of which dictates how much substrate-rich blood returning from the placenta is streamed preferentially away from the liver and instead towards the heart. Herein, we aimed to use clinically relevant MRI techniques in sheep to measure indirectly induced changes in DV tone and the consequences of this on DV shunting, expressed as a ratio of umbilical vein (UV) flow [DV:UV (as a percentage)], and its impact on oxygen delivery to the fetal brain. At 116-117 days gestational age (term = 150 days), fetal sheep (n = 11) underwent surgery to implant vascular catheters. Fetal MRI scans were performed at 120-123 days gestational age. Phase contrast MRI and T

Indexed as

Adrenergic alpha-AntagonistsBrainFetal HypoxiaFetusHypoxiaOxygenAnimalsCerebrovascular CirculationFemaleMagnetic Resonance ImagingOxygen ConsumptionPhentolaminePregnancySheepUmbilical VeinsAdrenergic alpha-AntagonistsOxygenPhentolamineductus venosusfetushypoxaemiahypoxiamagnetic resonance imagingoxygen deliveryT2 oximetryα‐adrenergic

Identifiers

PMID41697275
PMCPMC13140686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.