Evidence map›Paper›PMID 41697196›Full record

Observational studyWorld journal of surgery2026

A Study of Time to Recovery Following Loss of Neuromonitoring Signal of the Recurrent Laryngeal Nerve in Thyroid Surgery.

Joyce Yu, Rathina Ragavan, Carolina Nylen, Ahmad Aniss, Stan Sidhu, Alexander Papachristos, Daniel Novakovic, Thomas Stewart, Karl Ng, Hakan Ozoran and 1 more

Abstract readObservational Study
In one paragraph

Observational study in World journal of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joyce YuUniversity of Sydney, Camperdown, NSW, Australia.ORCID https://orcid.org/0009-0005-3178-8982
Rathina RagavanMacquarie University, Macquarie Park, NSW, Australia.
Carolina NylenDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Ahmad AnissUniversity of Sydney Endocrine Surgical Unit, St Leonards, Australia.
Stan SidhuUniversity of Sydney Endocrine Surgical Unit, St Leonards, Australia.
Alexander PapachristosUniversity of Sydney Endocrine Surgical Unit, St Leonards, Australia.
Daniel NovakovicUniversity of Sydney Voice Lab, Camperdown, NSW, Australia.
Thomas StewartUniversity of Sydney Voice Lab, Camperdown, NSW, Australia.
Karl NgDepartment of Neurology and Clinical Neurophysiology, Royal North Shore Hospital, Sydney, Australia.ORCID https://orcid.org/0000-0001-7973-3773
Hakan OzoranClinical Medical School, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-9316-0377
Mark SywakUniversity of Sydney Endocrine Surgical Unit, St Leonards, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInjuries of the recurrent laryngeal nerve (RLN) during thyroidectomy although infrequent can lead to major morbidity. Permanent RLN injury is uncommon; however, temporary neurapraxia and loss of signal (LOS) during intraoperative neuromonitoring (IONM) are seen more frequently. This study aimed to identify factors associated with type I (segmental) and II (global) LOS of the RLN during thyroid surgery and to analyze time to recovery of vocal cord function.

methodsThis observational retrospective cohort study included 3806 patients (2924 female, 76.8% and 882 male, 23.2%) who underwent hemi or total thyroidectomy in a tertiary center between January 2015 and March 2021. Regression analyses determined factors associated with LOS. Postoperative fibreoptic laryngoscopy was used to measure time to recovery of vocal cord function.

resultsRLN LOS occurred in 167 (2.7%) of 5983 nerves at risk during surgery. The rate of Type I and Type II LOS per nerve at risk was 1.4% and 1.3%, respectively. Compared with an indication of malignancy, toxic nodule was associated with 96% increased odds of LOS independent of age and sex (P < 0.001). Time to recovery was reduced for those with a Type II LOS (median 4 weeks) compared to Type I LOS (median 8 weeks and p = 0.04). Female sex and increasing age were independently associated with a longer duration to return of vocal cord function.

conclusionsTime to recovery of RLN function is significantly reduced for patients with Type II LOS. Toxic thyroid nodules were associated with a higher risk of LOS, and female sex and age are significantly associated with a longer time to recovery.

Indexed as

Intraoperative ComplicationsRecovery of FunctionRecurrent Laryngeal Nerve InjuriesThyroidectomyAdultAgedFemaleHumansLaryngoscopyMaleMiddle AgedRetrospective StudiesTime Factorsloss of signalneuromonitoringrecurrent laryngeal nerve injurythyroidectomy

Identifiers

PMID41697196
PMCPMC13006785

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.