ArticleBipolar disorders2026
A High-Accuracy and Easy-Use Differential Diagnosis Method of Bipolar Disorder Depressive Phase and Major Depressive Disorder Using a Wearable Near-Infrared Spectroscopy.
Article in Bipolar disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- A High-Accuracy and Easy-Use Differential Diagnosis Method of Bipolar Disorder Depressive Phase and Major Depressive Disorder Using a Wearable Near-Infrared Spectroscopy.Bipolar disorders · 2026Article
- Material context moderates the occupation-adjusted association between Visualization and prefrontal hemodynamics during naturalistic design: an exploratory wearable fNIRS study.Frontiers in neuroergonomics · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAlthough conventional multichannel near-infrared spectroscopy (cNIRS) has been reported to be useful in differentiating bipolar disorder depressive phase (BDD) from major depressive disorder (MDD), its utilization in real clinical practice remains limited. The objective of this study was to evaluate the performance of wearable NIRS (wNIRS), which is cheaper to install and easier to use than cNIRS, in differentiating between BDD and MDD, and to propose an optimal index for wNIRS.
methodsThe subjects were 16 BDD patients, 16 MDD patients, and 16 healthy controls. Changes in the total hemoglobin signal (Δ[total-Hb]) in the bilateral frontal cortex during a 60 s verbal fluency task (VFT) were measured using the HOT-2000, a wNIRS capable of reducing noise from skin blood flow. In addition to evaluating the discriminative performance of the integral and centroid values proposed in previous studies, the ratio of the mean values of the Δ[total-Hb] during the first 20 s and subsequent 40 s (20-40 ratio) during the VFT was also employed and assessed.
resultsOnly the 20-40 ratio showed significant differences between BDD and MDD, whereas the integral and centroid values did not. Using a cut-off value of 2.00 for the 20-40 ratio, the sensitivity and specificity of the BDD diagnosis were 100% and 93.4%, respectively.
conclusionsThe wNIRS measurements and the 20-40 ratio of the Δ[total-Hb] in the forehead area enabled more accurate differentiation between MDD and BDD than the conventional analysis.
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