ArticleDiagnostic cytopathology2026
Diagnostic Utility of Ki-67 Index on Cell Block Material for Grading Medullary Thyroid Carcinoma.
Article in Diagnostic cytopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Grading medullary thyroid carcinoma on fine needle aspiration biopsy specimens: a comparative study between manual counting and a deep learning platform.Journal of the American Society of Cytopathology · 2026Article
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4 authors.
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Abstract
introductionAn international grading system for medullary thyroid carcinoma (IMTCGS) was established in 2022. High-grade MTC is defined by the presence of one or more of the following features: mitotic index ≥ 5 per 2 mm MATERIALS AND
methodsA total of 60 FNA cases diagnosed as MTC or metastatic MTC between 2000 and 2025 were identified. Of these, 15 met the inclusion criteria: cell blocks with > 500 tumor cells and corresponding surgical specimens available. The Ki-67 proliferation index was assessed in hotspot regions using an online platform.
resultsThe study included 11 adults and 4 pediatric/adolescents with a median age of 50 years (range: 8-76). Based on the IMTCGS grading criteria, six cases were classified as high-grade and nine as low-grade. In low-grade tumors, the Ki-67 proliferation index on surgical resections ranged from < 1% to 4%, and all corresponding cell blocks showed Ki-67 rates of ≤ 1%. High-grade tumors exhibited Ki-67 indices ranging from 7% to 24%, with mitotic figures ranging from 1 to 14 per 2 mm
conclusionsGrading MTC using the Ki-67 proliferation index on cell blocks is challenging because of low cellularity and intratumoral heterogeneity in Ki-67 expression. In our study, this approach tended to undergrade high-grade MTC.
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