ArticleAccounts of chemical research2026
Synthesis, Structure, and Function of Heparan Sulfate Glycopolymers to Investigate Glycosaminoglycan-Protein Interactions.
Article in Accounts of chemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Synthetic Heparan Sulfate-like Oligosaccharides as Tools to Decipher Growth Factor Recognition.Journal of medicinal chemistry · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Heparan sulfate (HS), a highly sulfated glycosaminoglycan, varies in its disaccharide units, chain length, and sulfation patterns. HS structural diversity and its localization at cell surfaces and in the extracellular matrix enable HS interaction with a breadth of HS-binding proteins (HSBPs), HS thus being a co-receptor for other proteins and initiating various biological responses. Several designed and studied HS mimetics modulate HSBP activity implicated in various diseases. A key HSBP is heparanase (HPSE), which can cleave HS into smaller fragments, facilitating release of angiogenic growth factors, activating biological signals that may contribute to pathological conditions (promoting tumor development and metastasis), and enabling autoreactive immune cells to target insulin-producing β-cells. Thus, HPSE serves as a crucial target for disease therapy strategies. Several saccharide-based HS mimetics, designed as HSPE inhibitors, have advanced to clinical trials, but these sugar molecules were discontinued or suspended due to adverse effects from off-target HSBP interactions. Glycopolymers engineered to incorporate functionalized glycan residues into their polymeric backbones are a promising approach to retain endogenous HS' native biological activity, thereby enhancing therapeutic efficacy. Stereoselective formation of α-1,2-
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