ArticleJournal of traditional and complementary medicine2026
Elucidating the mechanism of traditional Chinese medicine formula (
Article in Journal of traditional and complementary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Cognitive Impairment Associated with Chemotherapy: Neuroimmunological Interactions, Gut-Brain Axis, and Therapeutic Approaches.Brain sciences · 2026Review
- Tumor-derived MG53 aggravates gastrointestinal cancer cachexia related muscle atrophy by inhibiting the TLR4/PI3K/AKT/FOXO3a signaling pathway.Frontiers in oncology · 2026Article
- Beyond survival: psychoneuroimmunology-driven cancer psychological rehabilitation-a paradigm shift from symptom management to biobehavioral remodeling.Frontiers in oncology · 2026Review
- Article
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8 authors.
Funding
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Abstract
Background: Cisplatin (DDP) is widely used to treat clinical malignant tumors, but it is also accompanied by serious adverse reactions, such as brain nervous system injury. In clinical treatment and animal experiments, traditional Chinese medicine formula ( Methods: A subcutaneous model of non-small cell lung cancer was established in mice, which were subsequently treated with YFSJ to evaluate the mechanism by which YFSJ alleviates DDP-induced chemobrain. Specifically, the effects of DDP and YFSJ on the brain nervous system of mice were evaluated by behavioral tests, brain blood flow observation, network pharmacology analysis, and histological analysis. In addition, the damaging effect of DDP on neurons and the effect of YFSJ on neurons were verified by Results: YFSJ reduced systemic inflammation in tumor-bearing mice, restored the function of the blood‒brain barrier (BBB) to reduce the amount of cisplatin in the brain, alleviated the decreases in voluntary activity and brain blood flow microcirculation induced by DDP, and alleviated brain tissue pyroptosis and ferroptosis caused by DDP. Conclusions: YFSJ maintains the functional stability of the BBB by inhibiting tumor-induced inflammation, thereby preventing chemobrain induced by nervous system damage caused by DDP entering brain tissue.
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