ReviewJournal of general and family medicine2026
Association Between Depression and Polypharmacy in Older Adults-A Systematic Review and Meta-Analysis.
Review in Journal of general and family medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Polypharmacy, Nutritional Risk, and Depressive Symptoms Among Older Outpatients at a Public Hospital: An Exploratory Cross-Sectional Study.Journal of multidisciplinary healthcare · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Depression and polypharmacy are both common among older adults and may be closely interrelated. Methods: This systematic review and meta-analysis examined the association between depression and polypharmacy by searching EMBASE, PubMed, Web of Science, and PsycINFO from inception to 18 May 2023. The review was registered in PROSPERO (CRD42022343619). Results: Eight studies met the inclusion criteria, with six rated high quality and two medium quality. Pooled analysis using a random-effects model demonstrated a strong association between depression and polypharmacy (OR = 2.49; 95% CI: 1.88-3.29; I² = 83%). Subgroup analyses revealed consistently elevated associations in both community-based and institutional/clinic-based populations. Conclusions: Depression is associated with polypharmacy among older adults. These findings underscore the importance of integrating mental health assessment into medication management strategies for older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.