ArticleScientifica2026
Comparison of the Effectiveness of Grape Seed Extract and Low-Level Laser Therapy in the Management of Dentin Hypersensitivity: A Randomized Controlled Trial.
Article in Scientifica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05927831 (Comparison of the Effectiveness of Grape Seed Extract), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Effectiveness of Grape Seed Extract (GSE) and Low-level Laser Therapy in the Management of Dentin Hypersensitivity: A Randomized Control Trial
Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the effectiveness of grape seed extract (GSE) and its combination with low-level laser therapy (LLLT) in alleviating pain from dentin hypersensitivity (DH) compared to LLLT alone. Methods: Patients aged 20-50 years with at least three sensitive teeth in different quadrants and baseline pain scores ≥ 2 on the visual analog scale (VAS) were recruited. Each tooth was randomly allocated to one of three groups: LLLT + placebo, GSE + placebo, or GSE + LLLT. Pain scores were recorded on Days 1, 3, and 7 using cold and air spray tests. Results: The GSE + LLLT group demonstrated the greatest reduction in pain sensitivity, showing a 72.8% decrease for air spray and 59.51% for the cold test at Day 3, compared to the LLLT or GSE groups alone. However, there were no statistically significant differences ( Discussion: The combination of GSE and LLLT may enhance early pain reduction in DH compared to individual treatments, but the improvement was not statistically significant. GSE presents a potentially feasible and patient-friendly alternative for DH management, warranting further clinical validation. Statistical Analysis Used: Data were collected and analyzed using IBM Statistical Package for the Social Sciences (SPSS) software program, Version 20.0 (IBM, Chicago, Illinois). General linear model-repeated measure ANOVA was carried out to assess the reduction in DH pain score among individual interventions and the comparison between the three interventions. The significance level was set at Conclusion: While GSE combined with LLLT showed the greatest numerical reduction in DH pain scores, the difference was not statistically significant. Further large-scale studies are recommended to confirm the clinical benefits of this combination. Trial Registration: ClinicalTrials.gov identifier: NCT05927831.
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