ArticleEnvironmental epidemiology (Philadelphia, Pa.)2026
Critical windows and risk thresholds of prenatal mixed air pollutant exposure for oligohydramnios: Evidence from a population‑based study.
Article in Environmental epidemiology (Philadelphia, Pa.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oligohydramnios is a clinically relevant but understudied pregnancy complication. This study evaluated the association between maternal exposure to mixed ambient air pollutants and the risk of oligohydramnios, focusing on identifying critical exposure windows and pollutant-specific concentration thresholds. Methods: We conducted a retrospective cohort study of 7,608 singleton live births from a tertiary hospital in northwestern China (2015-2019). Individual-level air pollution exposure was estimated by inverse distance weighting. Weighted quantile sum (WQS) and lagged WQS (lWQS) models were used to assess mixture effects and time-specific susceptibility. Restricted cubic spline models were applied to estimate concentration-response relationships and preventive thresholds of representative weeks and corresponding key pollutants. Results: The WQS index showed a significant joint effect for daily average exposure during whole pregnancy (odds ratio = 1.204, 95% confidene interval 1.049, 1.285), mainly driven by NO Conclusion: Maternal exposure to mixed air pollutants, particularly O
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