ArticleNeurologia croatica : glasilo Udruzenja neurologa Jugoslavije = official journal of Yugoslav Neurological Association2025
Diabetic striatopathy: cognitive and behavioral insights from case series and literature synthesis.
Article in Neurologia croatica : glasilo Udruzenja neurologa Jugoslavije = official journal of Yugoslav Neurological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Objective: Neurological disorders affecting the striatum are often associated with cognitive impairments and movement abnormalities. Diabetic striatopathy (DS), a rare complication of diabetes mellitus, has been traditionally associated with hyperkinetic movement disorders. However, comprehensive studies exploring the cognitive-behavioral aspects of this condition remain limited. We aimed to examine the cognitive and behavioral profiles of DS patients and explore mechanisms underlying the differential impact on motor versus cognitive-behavioral functions. Methods: Five consecutive Bengali patients with DS presenting with hemichorea, all without reported cognitive complaints prior to disease onset, underwent comprehensive neuropsychological assessments. These evaluations, conducted three months after the onset of movement disorders, included the Montreal Cognitive Assessment, Addenbrooke's Cognitive Examination-III, and Frontal Assessment Battery. Behavioral changes were assessed using the Neuropsychiatric Inventory. Results: The series included three women and two men (69.7 ± 5.6 years) with poorly controlled diabetes. The cognitive evaluation revealed variable impairments: attention deficits in two patients, executive dysfunction in one, recent memory impairment in two, and language deficits in two patients. Visuospatial and visuoperceptual functions were preserved, while behavioral manifestations included depression, apathy, and obsessive behavior, notably without psychotic features. A literature review identified five previously reported cases of DS with cognitive-behavioral manifestations. Conclusions: DS may produce less severe cognitive-behavioral impairments than other striatal disorders, likely due to selective circuit involvement and preserved compensatory mechanisms. This unique profile may reflect the acute nature of DS pathology, the potential reversibility of striatal changes, and preserved cortical-subcortical connectivity. These findings expand our understanding of DS beyond its classical motor manifestations.
Indexed as
Identifiers
41696534PMC12904212What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.