ArticleNew microbes and new infections2026
Whole genome analysis of carbapenem resistant
Article in New microbes and new infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Carbapenem resistant Methods: CRAB isolates were collected from 2018 to 2021 in two major hospitals in Dakar and subjected to antimicrobial susceptibility tests followed by whole genome sequencing and comprehensive bioinformatic analysis to identify resistance genes, mobile genetic elements (MGEs) and perform phylogeny analysis. Results: The isolates demonstrated an alarming level of resistance to multiple classes of antibiotics, categorizing them as extremely drug resistant. Genetically, they present 5 distinct sequence types (ST1, ST52, ST85, ST107, and ST164), and an average of 71.9% accessory genes. They also present 30 to 51 genes associated with resistance to numerous classes of antibiotics. These genes included those responsible for resistance to β-lactams (such as Conclusion: This pioneering study offers insight into the molecular mechanisms underlying carbapenem-resistant bacteria associated with HAIs in Senegal. These findings emphasize the critical need to implement surveillance programs particularly for carbapenem-resistant bacteria to gain a comprehensive understanding of their prevalence, propagation, impact on patient health outcomes, and prolonged hospital stays.
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