ReviewJournal of the advanced practitioner in oncology2026
Melatonin for the Management of Cancer-Related Fatigue in Breast Cancer: An Integrative Review.
Review in Journal of the advanced practitioner in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the impact of melatonin on cancer-related fatigue: a dose-response meta-analysis with GRADE evidence evaluation.BMC cancer · 2026Pooled it
- Insomnia in Breast Cancer: A Neglected Symptom Cluster.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is the most common cancer in women in the United States. The treatment of breast cancer has multiple side effects, including cancer-related fatigue (CRF). While physical activity has the strongest evidence in treating CRF, it is limited by a patient's functional status, disease, and safety concerns. Several studies have demonstrated that exogenous melatonin has improved depressive symptoms, insomnia, and sleep quality in breast cancer patients. However, few have focused on the effects of melatonin on CRF. This review explores the effect of melatonin on CRF in breast cancer patients. A review of current literature was conducted by searching PubMed, Cochrane, Scopus, and CINAHL databases. One hundred articles resulted, and after applying exclusion criteria, five articles were chosen for this review. Results showed a significant improvement in CRF in the studies utilizing 5 mg and 18 mg of melatonin in breast cancer patients undergoing chemotherapy or radiation. Melatonin can be considered an option for patients with breast cancer experiencing CRF, especially in the context of patients with physical limitations where exercise may not be an option. Additional research is needed to further evaluate the role and ideal dose of melatonin in the management of CRF.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.