ReviewMolecular therapy. Nucleic acids2026
Advances in lipid nanoparticles delivering genetic medicines for solid cancers.
Review in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- CRISPR-Cas9 in Cancer Therapy: Overcoming Delivery Barriers and Off-Target Effects for Clinical Translation.Health science reports · 2026Article
- Immunomodulatory LNP-mRNA therapeutics: The next phase of precision immuno-engineering.Molecular therapy. Nucleic acids · 2026Article
- Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Vaccine Adjuvants and Delivery Systems: A Comprehensive Review.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Nucleic acid lipid nanoparticle (LNP) technology has enabled the delivery of genetic medicines to solid tumors, opening new avenues for oncology therapeutics. Solid tumors present unique challenges to nucleic acid delivery because of their complex tumor microenvironment (TME), which acts as a barrier to NP delivery. Nevertheless, nucleic acid LNPs carry diverse genetic medicine modalities that can exert anti-cancer effects. The versatility of LNPs allows both local and systemic administrations for the delivery of gene therapy payloads to solid cancer, with the additional capability to selectively target specific cell types through conjugation of targeting ligands onto the LNPs. Genetic medicines delivered by LNPs can directly affect cancer cells, such as by suppressing oncogenic drivers and cancer pathways with small non-coding RNAs, or through overexpression of toxin genes or tumor suppressors. Non-cancer components of the tumor, such as tumor-associated vasculature, can also be targeted and disrupted to inhibit the structures that support tumor growth. Alternatively, LNP delivery of genetic medicines can indirectly elicit anti-tumor effects by modifying the immune state of the tumor environment through delivery of immunomodulatory cytokines, overexpression of activatable receptors to stimulate immune cells with agonists, or antigen-binding scaffolds to direct immunity towards a cancer cell. In this review, we summarize recent advances, challenges, and prospects of LNP delivery of genetic medicines to treat solid tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.