Evidence map›Paper›PMID 41696478›Full record

ReviewFrontiers in psychiatry2026

Neurobiological mechanisms and treatment of empathic pain in nonsuicidal self-injury.

Shu-Li Xu, Di Wu, Min Cai, Jing-Wen Li, Long-Biao Cui, Wen-Jun Wu

Abstract readReview
In one paragraph

Review in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shu-Li XuDepartment of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Di WuDepartment of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Min CaiDepartment of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Jing-Wen LiDepartment of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Long-Biao CuiDepartment of Psychiatry, 986 Hospital, Fourth Military Medical University, Xi'an, China.
Wen-Jun WuDepartment of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Empathic pain is defined as the experience of vicarious pain resulting from the observation of another person's suffering, and it involves complex neurobiological pathways that parallel those involved in direct pain perception. The intricate link between nonsuicidal self-injury (NSSI) and empathic pain lies in the fact that they share certain neurobiological mechanisms, particularly in the areas of emotion regulation and pain perception, and both phenomena involve brain networks involved in pain processing, emotion regulation, and social cognition. This review examines the current understanding of these mechanisms, including cellular and molecular pathways, changes in neural networks, and factors that influence the development of empathic pain. It also explores potential therapeutic strategies to address the complex interactions between empathic pain and NSSI, focusing on psychological interventions, pharmacological approaches, and novel neurostimulation techniques.

Indexed as

anterior cingulate cortex (ACC)empathic painneural networkneurobiologynonsuicidal self-injury

Identifiers

PMID41696478
PMCPMC12902301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.