ArticleFrontiers in psychiatry2026
CD4
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Emerging evidence supports the role of immune-mediated neuroinflammatory processes and disrupted sleep patterns in elevating susceptibility to major depressive disorder (MDD). Sleep disturbances, a hallmark clinical feature of MDD, have further been linked to changes in lymphocyte profiles. Nevertheless, the potential relationship between sleep disturbance and lymphocyte subpopulations characteristic in patients with MDD remains underexplored. Methods: In this study, flow cytometry was used to measure the proportion of peripheral blood CD4 Results: Baseline scores on the Hamilton Depression Rating Scale (HAMD) and Self-Rating Depression Scale (SDS) in patients with MDD were significantly higher than those in HCs. Regardless of antidepressant medication use, patients with MDD exhibited elevated proportions of CD4 Conclusions: Our findings demonstrate that patients with MDD comorbid with sleep disturbances exhibit elevated proportions of CD4
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