ArticleEXCLI journal2026
Metabolic profiling reveals potential biomarkers and underlying signaling pathways involved in mindfulness-based cognitive therapy-improved adolescent depression symptoms.
Article in EXCLI journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mindfulness-based cognitive therapy (MBCT) demonstrates significant efficacy in improving depressive symptoms and modulating metabolic profiles. However, the specific metabolite biomarkers and metabolic pathways underlying MBCT's therapeutic effects in adolescent depression remain unclear. This study aims to identify potential metabolite biomarkers and metabolic regulation pathways associated with MBCT improvement of adolescent depression. A global untargeted metabolomics approach was employed to analyze plasma samples from 35 adolescents with depression undergoing MBCT, 35 receiving conventional treatment (CT), and 30 age- and sex-matched healthy controls. MBCT significantly alleviated anxiety and depression symptoms of adolescent patients visualized by SDS, GAD-7, and SCL-90 scores (
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