Evidence map›Paper›PMID 41696415›Full record

ArticleOpen forum infectious diseases2026

Prevalence of CSF HIV VIRAL Escape and Associations With Neurocognitive Outcomes Among HIV-Associated Meningitis Survivors: A Cohort Study.

Laura Nsangi, Gila Hale, Biyue Dai, Kathy Huppler Hullsiek, Asmus Tukundane, Alice Namudde, Grace B Menya, Peruth Ayebare, Lydia Nankungu, Olivie C Namuju and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Laura NsangiInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID https://orcid.org/0009-0007-3992-0743
Gila HaleInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID https://orcid.org/0009-0009-2705-108X
Biyue DaiDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-4747-3687
Kathy Huppler HullsiekDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-2754-3473
Asmus TukundaneInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID https://orcid.org/0009-0001-1444-8389
Alice NamuddeInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Grace B MenyaInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Peruth AyebareInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Lydia NankunguInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Olivie C NamujuInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID https://orcid.org/0000-0001-8358-5064
Susan MulwanaInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Mable KabahubyaInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
David B MeyaInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
David R BoulwareDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-4715-0060
Fiona V CresswellInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Nathan C BahrDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-9431-8938
Mahsa AbassiDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-9601-3006
Jayne EllisInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Funding

Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related MeningitisR01NS086312 · NINDS · UNIVERSITY OF MINNESOTA · PI David R Boulware, David Bisagaya Meya · 2013 to 2026
$8.3M
Targeting Neuropathogenesis of Altered Mental Status to Improve Survival in Cryptococcal MeningitisK23NS122601 · NINDS · UNIVERSITY OF MINNESOTA · PI ABASSI, MAHSA · 2021 to 2025
$1.1M
Minnesota-Makerere-Mbarara Neuro-Infectious Disease Research Training ConsortiumD43TW012266 · FIC · UNIVERSITY OF MINNESOTA · PI David R Boulware, David Bisagaya Meya · 2024 to 2026
$747k
Midcareer Mentoring for Clinical Research in HIV/AIDS-related cryptococcal and TB meningitisK24AI184270 · NIAID · UNIVERSITY OF MINNESOTA · PI David R Boulware · 2024 to 2026
$648k
Late Neurological Sequelae after Cryptococcal MeningitisR21TW012988 · FIC · INFECTIOUS DISEASES INSTITUTE · PI NSANGI, LAURA JOAN · 2024 to 2025
$347k
FIC NIH HHS D43 TW012266FIC NIH HHS R21 TW012988NIAID NIH HHS K24 AI184270NINDS NIH HHS K23 NS122601NINDS NIH HHS R01 NS086312Wellcome Trust
6 · The paper itself

Abstract

Among this prospective cohort of 93 Ugandan adults who survived HIV-associated cryptococcal or tuberculous meningitis, baseline secondary cerebrospinal fluid (CSF) HIV viral escape was highly prevalent and was associated with better neurocognitive outcomes at 3 months. Individuals with secondary CSF HIV viral escape were more likely to be antiretroviral therapy-naïve and to exhibit CSF pleocytosis.

Indexed as

cryptococcalCSF viral escapeHIV viremiameningitisneurocognitive impairmenttuberculous

Identifiers

PMID41696415
PMCPMC12897537

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.