Evidence map›Paper›PMID 41696380›Full record

ArticleIndian journal of anaesthesia2026

Safety and efficacy of remimazolam in general anaesthesia during laparoscopic cholecystectomy: A systematic review and meta-analysis of randomised controlled trials.

Mohamed Abuelazm, Shroog Alanazi, Rayyan Altemani, Salman Aljaber, Abdullah Almosa, Ali Aljuraifani, Mamdouh Alrugaibah, Mohammed Albalawi, Fahad Alwisiydi, Rayan Muawad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohamed AbuelazmPrimary Care Physician, Faculty of Medicine, Tanta University, Egypt.ORCID https://orcid.org/0000-0002-2514-0689
Shroog AlanaziIntern, College of Medicine, University of Hail, Saudi Arabia.ORCID https://orcid.org/0009-0005-4407-9392
Rayyan AltemaniResident, Internal Medicine, University of Utah, USA.ORCID https://orcid.org/0000-0002-9252-1190
Salman AljaberIntern, College of Medicine, Qassim University, Saudi Arabia.ORCID https://orcid.org/0009-0001-5537-5710
Abdullah AlmosaIntern, College of Medicine, Almaarefa University, Saudi Arabia.ORCID https://orcid.org/0009-0001-9136-8980
Ali AljuraifaniIntern, College of Medicine, Qassim University, Saudi Arabia.ORCID https://orcid.org/0009-0001-9916-6291
Mamdouh AlrugaibahIntern, College of Medicine, Qassim University, Saudi Arabia.ORCID https://orcid.org/0009-0009-8231-5316
Mohammed AlbalawiIntern, College of Medicine, Jouf University, Saudi Arabia.ORCID https://orcid.org/0009-0005-0772-644X
Fahad AlwisiydiIntern, College of Medicine, Almaarefa University, Saudi Arabia.ORCID https://orcid.org/0009-0006-4494-8874
Rayan MuawadConsultant, Pediatric Anaesthesia Department, King Abdullah Specialist Children Hospital, Saudi Arabia.ORCID https://orcid.org/0009-0009-4391-3022

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Laparoscopic cholecystectomy (LC) presents anaesthetic challenges such as haemodynamic instability and postoperative complications. Remimazolam (RMZ), a novel ultra-short acting benzodiazepine, has emerged as a promising alternative to the standard propofol, with a potentially superior safety profile. This study aimed to compare the efficacy and safety of RMZ with propofol for anaesthesia during LC. Methods: A systematic review and meta-analysis were conducted to synthesise evidence from randomised controlled trials (RCTs). A search of PubMed, Web of Science, Scopus, and Google Scholar through May 2025 was conducted. We pooled dichotomous outcomes using risk ratios (RRs) and continuous outcomes using mean differences (MDs), and 95% confidence intervals (CIs). Results: Six RCTs involving 452 patients were included in the analysis. Compared to the control group, RMZ was associated with a significantly longer anaesthesia onset time (MD: 13.26, 95% CI: 0.47, 26.05, Conclusion: With uncertain evidence, RMZ significantly prolonged anaesthesia onset time, recovery time, and time to PACU discharge compared to control in patients undergoing LC. Still, RMZ improved patient comfort through significantly decreased incidence of injection pain and is associated with a comparable haemodynamic safety profile to propofol.

Indexed as

Cholecystectomyhaemodynamiclaparoscopymeta-analysisnauseapainpropofolrecoveryremimazolamsafetysedationsurgery

Identifiers

PMID41696380
PMCPMC12900246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.