Evidence map›Paper›PMID 41696359›Full record

ReviewFrontiers in cellular and infection microbiology2026

Encapsulated probiotics as antimicrobial agents: mechanisms and delivery strategies against multidrug-resistant pathogens.

Ulpan Kart, Dinara Smagulova, Dana Khairetdinova, Aigul Raimbekova, Gonzalo Hap Hortelano

Abstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ulpan KartDepartment of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.
Dinara SmagulovaDepartment of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.
Dana KhairetdinovaDepartment of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.
Aigul RaimbekovaDepartment of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.
Gonzalo Hap HortelanoDepartment of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.

Funding

FDA HHS U18 FD004742
6 · The paper itself

Abstract

The rapid escalation of antimicrobial resistance (AMR) has rendered many conventional antibiotics ineffective, emphasizing the need for alternative therapeutic approaches. Probiotics have emerged as promising biotherapeutic agents capable of inhibiting multidrug-resistant (MDR) pathogens through diverse mechanisms, including secretion of antimicrobial metabolites (bacteriocins, organic acids, short-chain fatty acids, and hydrogen peroxide), competitive exclusion, quorum-sensing interference, and immune modulation. However, their clinical application is limited by poor stability under environmental and gastrointestinal stressors. Encapsulation technologies, particularly those employing natural biopolymers such as alginate, chitosan, pectin, carrageenan, and gelatin, have substantially improved probiotic viability, storage stability, and site-specific release. Recent advances in semi-synthetic and synthetic carriers, including PLGA, PVA, Eudragit

Indexed as

Anti-Infective AgentsDrug Resistance, Multiple, BacterialProbioticsAnimalsDrug CarriersHumansAnti-Infective AgentsDrug Carriersantimicrobial resistancebacteriocinsencapsulationmultidrug-resistant pathogensprobiotics

Identifiers

PMID41696359
PMCPMC12894281

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.