ArticleFrontiers in cellular and infection microbiology2026
Clinical characteristics and prognostic impact of Burkholderia cepacia complex colonization and infection in patients with hematologic malignancies.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: In recent years, there has been an increasing number of reports on infections caused by the Burkholderia cepacia complex (Bcc). However, the clinical characteristics and prognosis of Bcc infections in patients with hematological malignancies remain unreported. This study aimed to delineate the clinical trajectory from colonization to active infection and to identify prognostic factors influencing outcomes in hematologic malignancy patients with Bcc colonization. Methods: We conducted a retrospective analysis of 185 hematological malignancy patients with Bcc colonization at the Department of Hematology, The First Affiliated Hospital of Soochow University, from November 2019 to November 2022. This study aimed to identify independent risk factors for mortality in this patient population. Results: Respiratory failure ( Conclusion: Progression from Bcc colonization to active infection, particularly in HSCT recipients, signifies a critical juncture with markedly increased mortality. Implementing vigilant surveillance protocols to prevent this transition is paramount for improving survival in this vulnerable population.
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