ArticleACS omega2026
Antibacterial and Osteoinductive Ti Implants Derived from MOF-Engineered Magnesium Oxide.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
Ti-based implants are widely applied in orthopedic repair and reconstruction, but their intrinsic bioinertness and susceptibility to implant-associated infection (IAI) remain major clinical challenges. To simultaneously improve antibacterial activity and osteogenic performance, we developed a structurally uniform and morphologically controllable MgO functional coating (Ti-MC) on Ti using a metal-organic framework (MOF)-derived strategy. Ti-MC exhibits a dual-mode antibacterial effect: (i) creating a sustained weakly alkaline microenvironment that directly induces reactive oxygen species (ROS) generation in bacteria, causing membrane disruption and (ii) activating neutrophil extracellular traps (NETs) formation to achieve immune-mediated antibacterial activity. This synergistic mechanism effectively inhibited both
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Registered trials
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