Evidence map›Paper›PMID 41696278›Full record

ArticleACS omega2026

Carbon-11 Isotopic Radiolabeling of CP31398 and Development of a Fluorine-18 Derivative to Target Protein p53 with PET Imaging.

Sébastien Beuché, Soizic Martin Aubert, Philippe Robin, Caroline Denis, Denis Servent, Bertrand Kuhnast, Charles Truillet, Fabien Caillé

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sébastien BeuchéUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay (BioMaps), 4 place du Général Leclerc 91401 Orsay, France.
Soizic Martin AubertUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay (BioMaps), 4 place du Général Leclerc 91401 Orsay, France.
Philippe RobinUniversité Paris-Saclay, CEA, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, 91191 Gif sur Yvette, France.
Caroline DenisUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay (BioMaps), 4 place du Général Leclerc 91401 Orsay, France.
Denis ServentUniversité Paris-Saclay, CEA, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, 91191 Gif sur Yvette, France.
Bertrand KuhnastUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay (BioMaps), 4 place du Général Leclerc 91401 Orsay, France.ORCID https://orcid.org/0000-0002-5035-4072
Charles TruilletUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay (BioMaps), 4 place du Général Leclerc 91401 Orsay, France.
Fabien CailléUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay (BioMaps), 4 place du Général Leclerc 91401 Orsay, France.ORCID https://orcid.org/0000-0003-0088-7337

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutant protein p53, a central driver of pro-oncological deregulations, is widely recognized as a biomarker of cancer aggressiveness and therapy resistance. In a personalized medicine perspective, positron emission tomography (PET) imaging of mutant p53 would be a powerful tool for patient stratification and drug development. However, to date, no PET radiotracers directly targeting mutant p53 have been reported. Inspired by the CP31398 drug, which stabilizes p53 conformation and treats tumors expressing mutant p53, we designed two novel PET radiotracers labeled with either carbon-11 by isotopic labeling or fluorine-18, namely [

Identifiers

PMID41696278
PMCPMC12902872

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.