Evidence map›Paper›PMID 41696255›Full record

ArticleACS omega2026

Black Phosphorus Nanosheets Induce Ferroptosis in Oral Squamous Cell Carcinoma via PI3K-AKT-SREBP1 Signaling Pathway-Mediated Lipogenesis.

Xianghuai Zheng, Yue Zou, Qinkai Xie, Hao Dong, Jiating Lin, Xianxian Zhuang, Ruoting Xian, Shaobing Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xianghuai ZhengDepartment of Oral and Maxillofacial Surgery, Stomatological Hospital, School of Stomatology, Southern Medical University, No. 366 South Jiangnan Avenue, Haizhu District, Guangzhou 510280, China.ORCID https://orcid.org/0000-0003-3428-4542
Yue ZouCenter of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, No. 366 South Jiangnan Avenue, Haizhu District, Guangzhou 510280, China.
Qinkai XieCenter of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, No. 366 South Jiangnan Avenue, Haizhu District, Guangzhou 510280, China.
Hao DongCenter of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, No. 366 South Jiangnan Avenue, Haizhu District, Guangzhou 510280, China.ORCID https://orcid.org/0000-0002-5139-683X
Jiating LinCenter of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, No. 366 South Jiangnan Avenue, Haizhu District, Guangzhou 510280, China.
Xianxian ZhuangCenter of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, No. 366 South Jiangnan Avenue, Haizhu District, Guangzhou 510280, China.
Ruoting XianCenter of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, No. 366 South Jiangnan Avenue, Haizhu District, Guangzhou 510280, China.
Shaobing LiCenter of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, No. 366 South Jiangnan Avenue, Haizhu District, Guangzhou 510280, China.ORCID https://orcid.org/0000-0002-5897-6300

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) presents significant therapeutic challenges due to chemoresistance and limited treatment modalities. Black phosphorus nanosheets (BPNSs), a novel two-dimensional nanomaterial, have shown promising antitumor effects. However, their role in inducing ferroptosis in OSCC and the underlying mechanisms remain to be elucidated. In this study, BPNSs were prepared via liquid-phase exfoliation, and their effects on the OSCC CAL-27 cells were subsequently evaluated. In vitro, BPNSs dose-dependently inhibited CAL-27 cell proliferation, induced G2/M phase arrest, and triggered ferroptosis, indicated by increased intracellular Fe

Identifiers

PMID41696255
PMCPMC12903157

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.