Evidence map›Paper›PMID 41696207›Full record

ArticleACS omega2026

Capsaicin-Inspired Hydroxamate Hybrids as Selective HDAC6 Inhibitors with Antiproliferative Activity in Hematological Malignancies.

Lara Gimenez Borges, Thais Nascimento de Oliveira Alves, Sandra Valeria Vassiliades, Jorge Antonio Elias Godoy Carlos, Karoline de Barros Waitman, Sebastian Hilscher, Mike Schutkowski, Wolfgang Sippl, Maurício Temotheo Tavares, Monica Franco Zannini Junqueira Toledo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lara Gimenez BorgesDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-900, Brazil.
Thais Nascimento de Oliveira AlvesDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-900, Brazil.
Sandra Valeria VassiliadesDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-900, Brazil.
Jorge Antonio Elias Godoy CarlosDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-900, Brazil.
Karoline de Barros WaitmanDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-900, Brazil.
Sebastian HilscherFaculty of Biosciences, Martin-Luther-University of Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID https://orcid.org/0009-0003-0611-7365
Mike SchutkowskiFaculty of Biosciences, Martin-Luther-University of Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID https://orcid.org/0000-0003-0919-7076
Wolfgang SipplFaculty of Biosciences, Martin-Luther-University of Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID https://orcid.org/0000-0002-5985-9261
Maurício Temotheo TavaresDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.
Monica Franco Zannini Junqueira ToledoDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-900, Brazil.ORCID https://orcid.org/0000-0001-7974-4480
Letícia Veras Costa-LotufoDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-900, Brazil.ORCID https://orcid.org/0000-0003-1861-5153
Thales KronenbergerInterfaculty Institute of Microbiology and Infection Medicine (IMIT), University of Tübingen, Tübingen 72076, Germany.ORCID https://orcid.org/0000-0001-6933-7590
João Agostinho Machado-NetoDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-900, Brazil.ORCID https://orcid.org/0000-0002-2937-8109
Roberto Parise-FilhoDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-900, Brazil.ORCID https://orcid.org/0000-0002-9311-7245

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of capsaicin-inspired benzodioxol-benzyl-hydroxamate hybrids was synthesized in three steps with high purity (≥95%) and excellent yields (71-94%). Compounds

Identifiers

PMID41696207
PMCPMC12903172

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.