Evidence map›Paper›PMID 41695999›Full record

ArticleJournal of dermato-oncology2026

Blue light and ultraviolet radiation: comparative biophysical properties and their roles in skin carcinogenesis and photoaging.

Robert L McKay, Shiyong Wu

Abstract read
In one paragraph

Article in Journal of dermato-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert L McKayDepartment of Chemistry and Biochemistry, Ohio University, Athens, OH, USA.ORCID 0000-0003-1925-5655
Shiyong WuDepartment of Chemistry and Biochemistry, Ohio University, Athens, OH, USA.ORCID 0000-0002-4104-4160

Funding

Molecular mechanisms of cNOS-mediated NF-kappa B activation in regulation of ultraviolet B light-induced photocarcinogenic responsesR01ES030425 · NIEHS · OHIO UNIVERSITY ATHENS · PI WU, SHIYONG · 2019 to 2023
$1.7M
NIEHS NIH HHS R01 ES030425
6 · The paper itself

Abstract

Ultraviolet radiation (UVR), especially UVB and UVA, drives photoaging and carcinogenesis, whereas blue light (BL, 400-500 nm) remains less studied. Evidence shows BL induces melanogenesis, generates reactive oxygen species, impairs deoxyribonucleic acid (DNA) repair, and accelerates pigmentation and oxidative stress. Though not directly linked to skin cancer, BL amplifies UVR damage and hastens photoaging, yet also suppresses tumor growth by promoting apoptosis, revealing dual context-dependent effects. This review highlights BL's biological and clinical relevance, phototype-dependent responses, and mechanistic uncertainties. Expanding photoprotection beyond UVR to include BL is essential for comprehensive, evidence-based strategies safeguarding skin health across diverse populations.

Indexed as

blue lightphotoagingskin carcinogenesisUltraviolet radiation

Identifiers

PMID41695999
PMCPMC12903870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.