Evidence map›Paper›PMID 41695983›Full record

ArticleJournal of tropical medicine2026

Exploring the Natural Products Atlas (NPAtlas) Database for Hunting Prospective Irreversible Covalent DprE1 Inhibitors With Antitubercular Activity: An Integrated

Mahmoud A A Ibrahim, Doaa G M Mahmoud, Sherif S Ebada, Peter A Sidhom, Gamal A H Mekhemer, Mohamed-Elamir F Hegazy, Yanshuo Han, Tarad Abalkhail

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tropical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mahmoud A A IbrahimChemistry Department, Faculty of Science, Minia University, Minia, 61519, Egypt, minia.edu.eg.ORCID https://orcid.org/0000-0003-4819-2040
Doaa G M MahmoudChemistry Department, Faculty of Science, Minia University, Minia, 61519, Egypt, minia.edu.eg.ORCID https://orcid.org/0009-0005-3141-9458
Sherif S EbadaDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt, asu.edu.eg.ORCID https://orcid.org/0000-0002-2753-0031
Peter A SidhomDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt, tanta.edu.eg.ORCID https://orcid.org/0000-0003-2579-6351
Gamal A H MekhemerChemistry Department, Faculty of Science, Minia University, Minia, 61519, Egypt, minia.edu.eg.ORCID https://orcid.org/0000-0003-2474-076X
Mohamed-Elamir F HegazyChemistry of Medicinal Plants Department, National Research Centre, Giza, 12622, Egypt, nrc.sci.eg.ORCID https://orcid.org/0000-0002-0343-4969
Yanshuo HanSchool of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China, dlut.edu.cn.ORCID https://orcid.org/0000-0002-4897-2998
Tarad AbalkhailDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia, ksu.edu.sa.ORCID https://orcid.org/0009-0005-7732-9933

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the second most deadly infectious disease worldwide after COVID-19, tuberculosis (TB) remains a pressing global health issue, further aggravated by multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) strains. There is an urgent need to identify new anti-TB treatments and novel therapeutics to confront drug resistance. The decaprenylphosphoryl-D-ribose oxidase (DprE1) is an essential protein for the biosynthesis of the mycobacterial cell wall, and its inhibition features a promising antitubercular strategy. NPAtlas was utilized as a reference database, comprising natural products with confirmed biological effects. The aim of the current study is to identify and prioritize promising nitro-containing natural products from the NPAtlas as potential covalent DprE1 inhibitors using advanced in silico approaches. Herein, the docking scores of 133 nitro-containing NPAtlas compounds were assessed using a covalent docking technique. Thereafter, NPAtlas compounds with docking scores lower than PBTZ169 (calc. -7.8 kcal·mol

Indexed as

binding energy calculationcovalent dockingDprE1molecular dynamics simulationNPAtlas

Identifiers

PMID41695983
PMCPMC12906241

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.