ArticleFrontiers in microbiology2026
Synergistic bactericidal activity of a ginsenoside-copper nano-agent against gram-positive and gram-negative biofilm bacteria.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Smart Nano-Antibiotics: AI-Guided Stimuli-Responsive Nanoplatforms for Precision Antimicrobial Therapy.Antibiotics (Basel, Switzerland) · 2026Review
- Copper Complexes: Emerging Micro- and Nanosystems for Dermatological Treatment.Pharmaceutics · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Biofilm-associated infections pose a formidable challenge due to their high tolerance to conventional antibiotics. While copper-based therapies offer a promising avenue, their clinical utility is severely limited by non-specific cytotoxicity and rapid deactivation. To address this, we engineered an intelligent, redox-responsive nanoplatform composed of Ginsenoside Re (GS) and copper (Cu Methods: GSR NPs were synthesized through a facile self-assembly process using GS and Cu Results: Characterization indicated the formation of uniform, ultra-small nanospheres stabilized by coordination and hydrogen bonds. GSR NPs remained stable in physiological buffers but exhibited responsive behavior in reducing microenvironments, triggering the release of active components and ROS generation. Consequently, GSR NPs displayed potent antibacterial activity and effectively disrupted established biofilms of both Conclusion: This work presents GSR NPs as a highly efficient and potentially low-toxicity antibacterial strategy. By overcoming the limitations of free copper ions, GSR NPs offer a promising therapeutic alternative for combating challenging biofilm-related infections.
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Registered trials
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